Vitinha opened the scoring before Mbappe swept home his first from a tight angle.
Arnaud Nordin scored for the hosts and Teji Savanier drew them level.
The France striker’s 50th-minute strike flew in off the crossbar and he finished his third from close range while Lee Kang-in and Nuno Mendes were also on the scoresheet for PSG.
Mbappe now has 24 league goals for the season after scoring his third hat-trick of the campaign.
It has been an unusual period for the 25-year-old who has been on the bench for two of PSG’s past three league games and came off at half time against Monaco where he watched the second half with his mother in the stands.
His benchings followed the announcement that he has agreed to join Real Madrid at the end of the season.
Before that Mbappe has one final chance to secure European glory with PSG who will face Barcelona in the Champions League quarter-finals.
He also looks set to win a fourth league title in the past five seasons, as PSG moved even further ahead of second-placed Brest, who drew 1-1 at home to Lille earlier in the day. —BBCSport